Development of a New Quantitative Bacterial Micro-Assay for Rapid Detection of Galactosemia: Application in Galactosemia Screening

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Quantitative Bacterial Micro-Assay for Rapid Diagnosis of Galactosemia: Application in Galactosemia Neonatal Screening

In the present study a new economic and rapid bacterial micro-assay for simultaneous detection and quantitative measurement of serum galactose was developed. Analysis of the standard curve showed a linearity range for galactose from 2 mg/dL to 180 mg/dL with a regression equation of Y = 0.013X ? 0.083; R² = 0.962. The advantage of the method is its ability to measure serum galactose quantitativ...

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quantitative bacterial micro-assay for rapid diagnosis of galactosemia: application in galactosemia neonatal screening

in the present study a new economic and rapid bacterial micro-assay for simultaneous detection and quantitative measurement of serum galactose was developed. analysis of the standard curve showed a linearity range for galactose from 2 mg/dl to 180 mg/dl with a regression equation of y = 0.013x ? 0.083; r² = 0.962. the advantage of the method is its ability to measure serum galactose quantitativ...

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Issues on universal screening for galactosemia.

Galactosemia is an inborn error of galactose metabolism, caused by an abnormality in the conversion of galactose and uridine diphosphoglucose to glucose-1-phosphate and uridine diphosphogalactose through the action of 3 sequential enzymes: galactokinase (GALK), galactose- 1-phosphate uridyltransferase (GALT), and uridine phosphogalactose 4-epimerase (GALE). The advent of newborn screening broug...

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Neonatal Screening: Cost-utility Analysis for Galactosemia

BACKGROUND Galactosemia is a congenital metabolic disorder that can damage the health of a newborn. Screening is an important step to prevent and treat this condition. Due to increasing health care costs and limited financial resources of health systems, the most suitable economic analysis tool should be applied. The aim of this study was to analyze the cost-utility of neonatal screening progra...

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neonatal screening: cost-utility analysis for galactosemia

background: galactosemia is a congenital metabolic disorder that can damage the health of a newborn. screening is an important step to prevent and treat this condition. due to increasing health care costs and limited financial resources of health systems, the most suitable economic analysis tool should be applied. the aim of this study was to analyze the cost-utility of neonatal screening progr...

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ژورنال

عنوان ژورنال: Journal of Applied Sciences

سال: 2008

ISSN: 1812-5654

DOI: 10.3923/jas.2008.3026.3031